The Nobel Prize in Chemistry 2017

How excited has this article about the Nobel Prize for Chemistry 2017 made me?

It explains the breakthroughs that have been made in Chemistry after the development of the electron microscope, since 1975 when Joachim Frank made electron microscopy applicable to reveal sharp three-dimensional structures from twodimensional images.

We have long been past the age of 2D in medical and biochemical imaging, but their discovery and develoment of cryo-electronmicroscopy for 3D images is clearly worth this Nobel Prize.

With the winners’ technique, enzymes are frozen in a water medium after being cooled instantly, making it possible for reagents along with the 3D structure of the enzyme to be visualized by the electron microscope.  This will make it possible to target for example pharmaceuticals more directly at the target site of an enzyme, making amazing drugs to heal illnesses.

Click here to view the original article at Nobleprize.org

 

 

My decision on Pathology

The decision to go and specialize, especially in Pathology, is not one to be taken lightly. Consequently I have given this decision a considerable amount of thought.

The dream started as a child still in primary school in Parys, Free State. As a budding and enquiring young scientist, I asked my father many questions about this and that, but one of the main questions which I asked was: Why was there no cure for HIV?

The question elicited many further questions which my father needed to answer for me, but one of them was about how would I go about finding a cure for HIV.  His advice included being very thorough in Biology, Chemistry, and especially Biochemistry. This sparked several thoughts in my mind and whenever I came across anything being related to Biology or Chemistry, I’m interested to read more, inquire more and find out more.

So I studied medicine because of an unquenchable desire to learn more about the origin of disease.  Although being well at Mechanics and Mathematics, I decided to embark on the journey of becoming a physician.  As a student I was fascinated by Medical Biochemistry, which we had as a subject from second semester.  I spent my afternoons and nights reading up and studying protein structures in 3D format on PyMol using the Protein Databank as reference and going through the amino acids in sequence trying to figure out why the protein looks as it is, why it functions like it does and how the one viewed is different from the one in our textbooks…

Medical Biochemistry and the Roche Poster of Biochemical Pathways enticed me so much when I saw it at the entrance of the Biochemistry Department that I put two versions of it up in my room when studying so that I could view the bigger picture.  In second and third year I was quite thorough at Medical Biochemistry and I enrolled at the University’s  Tutor Program and tutored the year-younger students in Medical Biochemistry as well as Physiology.  This granted me great pleasure, as well as something extra in the back pocket as a student.

My visit to China CMEF – Medical Equipment Fair

It has been some time now since being back from my trip to Shanghai,  China, in May,  visiting the China Medical Equipment Fair, the second largest Medical Device Expo in the world. I think it is worth mentioning some interesting points.  The reason for my visit was mainly to visit some of the manufacturers of medical equipment, learn more about the Chinese culture and browse through some of the newest technologies available.

After being back in South Africa I realized how much I have learned about the people in China.  The general impression I had about people there are that they tend to do things fast and not necessarily with precision in mind, but rather to get as much done as possible. This has come as a revelation of some kind and it was enlightening to realize why. The population in China is around 1.7 Billion. The population in Shanghai, the city where I spent most of my time, is around 27 Million. That is more than half the population of South Africa in one city! To keep things organized in such a huge city obviously needs on an individual as well as on community level a sense of respect for oneself and another, self-responsibility as well as the ability to get things done as fast as possible. The possible reason why, in general, things are done sometimes in a suboptimal quality though, is because to compete in such a large and diverse environment, an individual (whether a company or person) must get things done before the other individual.  This makes the startup individual or company a certain urgency to get the products out there into the market.

I have realized though, that the Chinese definitely has a huge proudness in their work.  With my visit to China Medical Equipment Fair, CMEF in 2017, I have realized, how with the proper praise, encouragement and clear communication, one can create amazing business opportunities and exceptional quality of products.